Global Education

Our work in Global Education seeks to provide awareness on various topics across Global Oncology. Our research interests include access to and prioritization of cancer drugs in LMICs including the WHO Essential Medicines List , LMIC participation in oncology clinical trials,  global cancer policy, and financial toxicity in LMICs. We also study the utility of artificial intelligence, locally developing “Me Too” drugs, drug repurposing, and training General Practitioners in oncology to address some of the challenges in global oncology. Finally, Dr. Gyawali is also the co-president for the annual ecancer Kathmandu event.

Relevant Publications:

  1. Koczwara B, Chan A, Jefford M, Lam WWT, Taylor C, Wakefield CE, Bhoo-Pathy N, Gyawali B, Harvet G, Lou Y, Pramesh CS, Takahashi M, Ke Y, Chan RJ. Cancer Survivorship in the Indo-Pacific: Priorities for Progress. JCO Glob Oncol. 2023. PMID: 36749908.
  2. Jenei K, Aziz Z, Booth C, Cappello B, Ceppi F, de Vries EGE, Fojo A, Gyawali B, Ilbawi A, Lombe D, Sengar M, Sullivan R, Trapani D, Huttner BD, Moja L. Cancer medicines on the WHO Model List of Essential Medicines: processes, challenges, and a way forward. Lancet Glob Health. 2022 Dec;10(12):e1860-e1866. PMID: 36183737. Altmetric score: 58
  3. Rubagumya F, Hopman WM, Gyawali B, Mukherji D, Hammad N, Pramesh CS, Zubaryev M, Eniu A, Tsunoda AT, Kutluk T, Aggarwal A, Sullivan R, Booth CM. Participation of Lower and Upper Middle-Income Countries in Clinical Trials Led by High-Income Countries. JAMA Netw Open. 2022 PMID: 35980637
  4. Denburg AE, Fundytus A, Khan MS, Howard SC, Antillon-Klussmann F, Sengar M, Lombe D, Hopman W, Jalink M, Gyawali B, Trapani D, Roitberg F, De Vries EGE, Moja L, Ilbawi A, Sullivan R, Booth CM. Defining Essential Childhood Cancer Medicines to Inform Prioritization and Access: Results From an International, Cross-Sectional Survey. JCO Glob Oncol. 2022 Jun;8:e2200034. PMID: 35749676.
  5. Dodkins J, Hopman WM, Wells JC, Lievens Y, Malik RA, Pramesh CS, Gyawali B, Hammad N, Mukherji D, Sullivan PR, Parkes J, Booth CM, Aggarwal A. Is Clinical Research Serving the Needs of the Global Cancer Burden? An analysis of contemporary global radiotherapy randomised controlled trials. Int J Radiat Oncol Biol Phys. 2022 Feb 10. PMID: 35151802.
  6. Akhade A, Sirohi B and Gyawali B*. Global consequences of the US FDA’s accelerated approval of cancer drugs. The Lancet Oncology. 2022 January. PMID: 35114117
  7. Khan SZ, Arecco L, Villarreal-Garza C, Sirohi B, Ponde NF, Habeeb B, Brandão M, Azim HA Jr, Chowdhury AR, Bozovic-Spasojevic I, Kovalenko I, Odhiambo A, Seid FU, Mutombo AB, Petracci F, Vidra R, Altuna SC, Petrova M, Kourie HR, Ozturk MA, Razeti MG, Lengyel CG, Talibova N, Mariamidze E, Sacardo KP, Duma N, Gyawali B, Trapani D, Tagliamento M, Lambertini M. Knowledge, Practice, and Attitudes of Physicians in Low- and Middle-Income Countries on Fertility and Pregnancy-Related Issues in Young Women With Breast Cancer. JCO Glob Oncol. 2022.PMID: 35025688
  8. Gyawali B, Carson L, Berry S and Moraes F. Challenges of globalization of cancer drug trials- recruitment in LMICs, approval in HICs. The Lancet Regional Health – Americas. 2022. Altmetric score: 51
  9. Wijeratne DT, Booth CM, Seneviratne S, Gyawali B, Jalink M, Soysa M, Abhayaratna S, Promod H, Wijesinghe P, Gunasekera S. Healthcare delivery for non-communicable diseases among breast cancer survivors in Sri Lanka: Is there a missed opportunity? Ecancermedicalscience. 2021. PMID: 34824624
  10. Fundytus A, Sengar M, Lombe D, Hopman W, Jalink M, Gyawali B, Trapani D, Roitberg F, De Vries EGE, Moja L, Ilbawi A, Sullivan R, Booth CM. Access to cancer medicines deemed essential by oncologists in 82 countries: an international, cross-sectional survey.Lancet Oncol. 2021. PMID: 34560006. Altmetric score: 121.
  11. Gyawali B*, Jalink M, Effing SMA#, Dalgarno N, Kolomitro K, Thapa N, Sharma Poudyal B, Berry S . Oncology training programmes for general practitioners: a scoping review ecancer 2021. 15 1241. PMID: 34267797
  12. Luo Z, Gyawali B*, Han S, Shi L, Guan X and Wagner AK. Can locally developed me-too drugs aid price negotiation? An example of cancer therapies from China. Seminars in Oncology 2021. PMID: 33875231
  13. Cherla A, Naci H, Kesselheim AS, Gyawali B, Mossialos E. Assessment of Coverage in England of Cancer Drugs Qualifying for US Food and Drug Administration Accelerated Approval. JAMA Internal Medicine. 2021. PMID: 33616607. Altmetric score: 67
  14. Wells JC, Sharma S, Del Paggio JC, Hopman W, Gyawali B, Mukherji D, Hammad N, Pramesh CS, Aggarwal A, Sullivan R and Booth C. An Analysis of Contemporary Oncology Randomized Clinical Trials From Low/Middle-Income vs High-Income Countries. JAMA Oncol. 2021. PMID: 33507236 Altmetric Score: 132
  15. Poudyal B, Gyawali B and Rondelli D. The need for locally generated data in haematology: a real‐world experience of aplastic anaemia in Nepal. British Journal of Haematology. 2020. PMID: 33216359
  16. Gyawali B*, Bouche G, Crisp N. and Andre N. Challenges and opportunities for cancer clinical trials in low- and middle-income countries. Nature Cancer 1, 142–145 (2020). Altmetric score: 135
  17. Gyawali B*. Does global oncology need artificial intelligence? The Lancet Oncology. May 2018. PMID: 29726374 Altmetric score: 54
  18. Bhatt VR, Chen B, Gyawali B and Lee SJ. Socioeconomic and health system factors associated with lower utilization of hematopoietic cell transplantation in older patients with acute myeloid leukemia. Bone Marrow Transplant. 2018 March. PMID: 29588500
  19. Gyawali B*, Patziarka P, Crispino S and Bouche G. Does the oncology community have a rejection bias when it comes to repurposed drugs? Ecancer 2018, ed76. Published 16 Jan, 2018. PMID: 29456622
  20. Gyawali B (2017).* Low-value practices in oncology contributing to financial toxicity. Ecancermedicalscience. 11: 727  (PMID: 28386297). Altmetric score: 118.
  21. Gyawali B* and Iddawela M. Bevacizumab in advanced cervical cancer: issues and challenges for low- and middle- income countries. Journal of Global Oncology. 3, no. 2 (April 2017) 93-97. (PMID: 28717748)
  22. Gyawali B*, Shimokata T, Honda K, Tsukuura T and Ando Y. Should low-income countries spend on breast-cancer screening? Cancer Causes and Control (2016) 27:1341. (PMID: 27680017)
  23. Gyawali B*, Poudyal B and Iddawela M. Cheaper options in the prevention of Chemotherapy Induced Nausea and Vomiting. Journal of Global Oncology 2016;2:3. 145-153. PMID: 28717694
  24. Gyawali B*. Me, too. Comments and Controversies. Journal of Global Oncology 2, no. 3 (June 2016) 99-104. PMID: 28717688
  25. Gyawali B*, Koomulli-Parambil S, Iddawela M. Continuous versus intermittent docetaxel for metastatic castration resistant prostate cancer. Critical Reviews in Oncology/Hematology.  2016;102. (PMID : 27157868)